Acquired (Drug-Induced) Long QT (di-LQT)

A prolonged QT interval i can occur in response to acute and chronic use of certain prescription medications; this is known as Acquired or Drug-Induced Long QT (diLQT). These medications are prescribed when their benefits outweigh the risks of QT prolongation, especially when limited treatment options are available. The risk of QT prolongation with certain medications increases with underlying risk factors, including congenital Long QT Syndrome and/or abnormalities in bodily electrolytes (such as low potassium or low magnesium). These situations must be carefully assessed and managed by a healthcare provider.

Acquired Long QT Syndrome & SGK1

We are exploring the use of our novel SGK1 inhibitors as potential therapies to treat acquired or drug-induced Long QT (diLQT). In our Wave I Part 1 clinical proof-of-efficacy study, our lead compound (LQT-1213) demonstrated rapid and meaningful reduction in the QT interval when a prolonged QT was induced by dofetilide, a drug known to cause diLQT.

If you are concerned about your personal health please speak to a specialist or your health care provider urgently.